A. Internal quality control

In all tests we include known positive and negative sera / CSF- controls. Most positive results are repeated both for confirmation and for a quantitative or semi-quantitative determination of the antibody titer. Also, already for the diagnosis of most diseases we apply two different methods (particularly in the case of a positive result) or we search for more than one biomarkers. Examples include testing for antibodies against AChR and MuSK (by standard RIA and new highly sensitive RIA, and with CBA when requested), against AQP4 (by CBA and RIA), against Titin (by ELISA and when deemed useful by RIA as well), against AQP1 (ELISA with whole AQP1 and with peptides corresponding to its extracellular and intracellular domains), against  paraneoplastic antigen (by immunoblotting, tissue immunofluorescence and CBA), for multiple sclerosis (oligoclonal bands and quantitative IgG measurements albumin), for CJD (comparison of values for three proteins) and Alzheimer (comparison of values for four proteins). We make efforts the double check to be extended to almost all the tests we perform.

B. External quality control

We participate in several international quality control programs for as many of our tests are available (such as antibodies to the AChR, gangliosides, paraneoplastic antigens, oligoclonal bands in multiple sclerosis, myopathy antigens, NMDAR, CASPR1, LGI1, GAD, AQP4, Mup44 and the four CSF proteins involved in Alzheimer disease. For most of the other tests (for which we do not know the availability of organized external quality control), we confirm the reliability of our results by sending selected samples to collaborating international reference laboratories for confirmation. For some rare and very recent tests, we offer them in cooperation with certified reference laboratories abroad, until we adopt them in our laboratory. These include the detection of antibodies against ryanodine receptor, ganglionic AChR, GABAAR, mGluR1, mGluR5, Iglon5, VGCC type-N and dopamine receptors.

C. ISO

We operate under the international quality management standard ISO 9001: 2015.


 

• Patients or clinics could either send us approximately 5 ml serum, or patients can visit us for blood sampling (Monday to Friday: 7:30 to 18:00, Saturday 9:00-11:00). It is also possible, when necessary, that we do blood sampling at the patient’s place.

• To test for oligoclonal bands for multiple sclerosis we must receive > 0.5 ml cerebrospinal fluid and about 5 ml of blood serum. The serum and CSF should be taken on the same day, kept in a cool environment (preferably about 4°C), and sent to us as soon as possible.

• To test for Alzheimer we must firstly make arrangements with your doctor before collecting the cerebrospinal fluid.


 

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   Eslin  3, Ampelokipoi, Athens 11523, Tel 210-6411060 & 210-6429969, Fax 210-6411067

Emails: info(at)neurodiagnostics.gr  & stzartos(at)gmail.com

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